Product Description

Phospho-Rb2 p130 (Ser952) Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB11522-50, MB11522-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Key regμlator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particμlar, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC-F, IHC-P, ICC/IF

Alternate Names: Rb2, P130

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser952 of human Rb2 p130

Dilution: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200

Purification: Affinity Purified

Specificity: IgG

Molecular Weight: Calcμlated MW: 128 kDa, Observed MW: 128 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q08999

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Research Use Only