Phospho-Rb2 p130 (Thr986) Monoclonal Antibody-MB10413

Phospho-Rb2 p130 (Thr986) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10413-50, MB10413-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q08999

Host: Rabbit

Reactivity: Human

Applications: WB,IP

All Applications: WB: 1/500-1/1000 IP: 1/20

Background: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-Rb2 p130 in K562Lysates using Phospho-Rb2 p130 antibody.

Bioworld Molecular Weight: Calculated MW: 128 kDa; Observed MW: 128 kDa

Specificity: IgG

Alternative Name: Rb2; P130

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Thr986 of human p130

Conjugate: Unconjugated

Modification: Phosphorylated