Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Monoclonal Antibody-MB11897

Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11897-50, MB11897-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q7L7X3/Q9H2K8/Q9UL54

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-P

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100

Background: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 116 kDa; Observed MW: 105,116,138 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-TAOK1/TAOK2 /TAOK3 in 3T3 lysates using Phospho-TAOK1/2/3 antibody., Western blot analysis of TAOK1 /TAOK2 /TAOK3 in Hela, A549, HL-60, U2OS, C6 lysates using TAOK1 /TAOK2 /TAOK3 antibody., Immunohistochemistry analysis of paraffin-embedded Human tonsil using TAOK1 /TAOK2 /TAOK3 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Alternative Name: DPK; JIK; hKFC-A; MAP3K18

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser181 of human TAOK1

Conjugate: Unconjugated

Modification: Phosphorylated