Phospho-TrkB (Tyr705) Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB11898-50, MB11898-100
Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Swiss-Prot: Q16620
Host: Rabbit
Reactivity: Human, Rat
Applications: WB
All Applications: WB: 1/500-1/1000
Background: The family of Trk receptor tyrosine kinases consists of TrkA, TrkB and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. TrkA regulates proliferation and is important for development and maturation of the nervous system. Point mutations, deletions and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA.
Purification and Purity: Affinity Purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Phospho-TrkB in Hela, A549, C6Lysates using Phospho-TrkB antibody.
Bioworld Molecular Weight: Calculated MW: 92 kDa; Observed MW: 140,90 kDa
Specificity: IgG
Alternative Name: NTRK2; TRKB; BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B
Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Tyr705 of human TrkB
Conjugate: Unconjugated
Modification: Phosphorylated