PI 3 Kinase Class 3 rabbit pAb - ES8477

PI 3 Kinase Class 3 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8477-50, ES8477-100

Citations, Manuals and MSDS Available upon request.

Background: catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate., cofactor:Manganese., function:Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes., similarity:Belongs to the PI3/PI4-kinase family., similarity:Contains 1 PI3K/PI4K domain., subunit:Probably forms a complex with AMBRA1 and BECN1 (By similarity). Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4., tissue specificity:Ubiquitously expressed, with a highest expression in skeletal muscle.,

Alternate Name: phosphoinositide-3-kinase, class 3

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse; Rat; Predicted:Cow:PIG

Immunogen: Synthetic Peptide of PI 3 Kinase Class 3

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 100kD

Human Gene ID: 5289

Human SWISS Prot NO: Q8NEB9

Subcellular Location: Midbody. Late endosome. Cytoplasmic vesicle, autophagosome. As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity).

Research Use Only