PI3 Kinase p85 alpha (1C8) Monoclonal Antibody-MB3331

PI3 Kinase p85 alpha (1C8) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB3331-50, MB3331-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: P27986

Host: Mouse

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-P

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100

Background: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG1

Bioworld Molecular Weight: Calculated MW: 84 kDa; Observed MW: 84 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry analysis of paraffin-embedded rat Liver Tissue using PI3 Kinase p85 alpha antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval., Immunohistochemical analysis of paraffin-embedded Human tonsils using PI3 Kinase p85 alpha antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval., Western blot analysis of PI3 Kinase p85 alpha in Jurkat, rat Brain, Raw264.7, Ramos, Raji lysates using PI3 Kinase p85 alpha antibody, Western blot analysis of PI3 Kinase p85 alpha in Hela, A549, HL-60, U2OS, C6 lysates using PI3 Kinase p85 alpha antibody.

Alternative Name: PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha

Immunogen: Purified recombinant protein expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified