PI3 Kinase p85 alpha (3H5) Monoclonal Antibody-MB3330

PI3 Kinase p85 alpha (3H5) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB3330-50, MB3330-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: P27986

Host: Mouse

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-P

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100

Background: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG1

Bioworld Molecular Weight: Calculated MW: 84 kDa; Observed MW: 84 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry analysis of paraffin-embedded rat Liver Tissue using PI3 Kinase p85 alpha antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval., Immunohistochemical analysis of paraffin-embedded Human tonsils using PI3 Kinase p85 alpha antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval., Western blot analysis of PI3 Kinase p85 alpha in THP-1, MCF-7, Goat Muscle, CHO-K1, C6, 3T3 lysates using PI3 Kinase p85 alpha antibody, Western blot analysis of PI3 Kinase p85 alpha in Hela, A549, HL-60, U2OS, C6 lysates using PI3 Kinase p85 alpha antibody.

Alternative Name: PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha

Immunogen: Purified recombinant protein expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified