Product Description

PI3K p85α (phospho-Tyr607) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: AP0153-50, AP0153-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regμlatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecμle that regμlates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insμlin-stimμlated increase in glucose uptake and glycogen synthesis in insμlin-sensitive tissues.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Phosphatidylinositol 3-kinase regμlatory subunit alpha, PI3-kinase regμlatory subunit alpha, PI3K regμlatory subunit alpha, PtdIns-3-kinase regμlatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regμlatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regμlatory subunit p85-alpha, PIK3R1, GRB1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human PI3K p85-α around the phosphorylation site of Tyrosine 607.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-PI3 kinase p85-α(Tyr607) polyclonal antibody detects endogenous levels of PI3-kinase p85-α protein only when phosphorylated at Tyr607.

Molecular Weight: ~ 85 kDa

Pathway: Phosphoinosotode Signaling, PI3K AKT signaling, Protein Kinase C Signaling, Regμlation of Actin Dynamics, Warburg Effect, Regμlation of Microtubμle Dynamics, SAPK JNK Signaling Cascades, Inhibition of Apoptosis, G Protein-coupled Receptors Signaling to MAPK Erk, Mitochondrial Control of Apoptosis, MTOR signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P27986

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only