Product Description

PIEZO1 Polyclonal Antibody

Catalogue Numbers: BS67341-50, BS67341-100

Sizes: 50µl, 100µl

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q92508

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/2000)

Background: Pore-forming subunit of a mechanosensitive non-specific cation channel.Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling.In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation.Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).Acts as sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of PIEZO1 protein.

Extra Notes: Western blot analysis of PIEZO1 expression in MCF7 (A) whole cell lysates.

Bioworld Molecular Weight: ~ 286 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: FAM38A; KIAA0233; Piezo-type mechanosensitive ion channel component 1; Membrane protein induced by beta-amyloid treatment; Mib; Protein FAM38A

Immunogen: Recombinant full length protein of human PIEZO1

Conjugate: Unconjugated

Modification: Unmodified