Pim-1 (phospho Tyr309) Polyclonal Antibody - RA21208

Pim-1 (phospho Tyr309) Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21208-50, RA21208-100

Citations, Manuals and MSDS Available upon request.

Background: Pim-1 proto-oncogene, serine/threonine kinase (PIM1) Homo sapiens The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810) .[provided by RefSeq, Aug 2011],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Alternative Names: PIM1; Serine/threonine-protein kinase pim-1

Applications: WB; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 5292

Protein MW (KDa): 45

SWISS: P11309

Source: Rabbit

Research Use Only