PINK1 rabbit pAb - ES10983

PINK1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES10983-50, ES10983-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008],

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from part region of human protein

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 63kD

Human Gene ID: 65018

Human SWISS Prot NO: Q9BXM7

Subcellular Location: Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion inner membrane; Single-pass membrane protein. Cytoplasm, cytosol. Localizes mostly in mitochondrion and the two smaller proteolytic processed fragments localize mainly in cytosol (PubMed:19229105). When mitochondria lose mitochondrial membrane potential following damage, PINK1 import is arrested, which induces its accumulation in the outer mitochondrial membrane, where it acquires kinase activity (PubMed:18957282).

Research Use Only