PinX1 rabbit pAb - ES6688

PinX1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6688-50, ES6688-100

Citations, Manuals and MSDS Available upon request.

Background: domain:The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity., function:Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor., similarity:Belongs to the PINX1 family., similarity:Contains 1 G-patch domain., subcellular location:In nucleoli and at telomere speckles., subunit:Binds to MCRS1, TERT and TERF1., tissue specificity:Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.,

Alternate Name: PINX1; LPTL; LPTS; PIN2/TERF1-interacting telomerase inhibitor 1; Liver-related putative tumor suppressor; Pin2-interacting protein X1; Protein 67-11-3; TRF1-interacting protein 1

Source: Rabbit

Applications: IHC; IF; ELISA

Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse;

Immunogen: The antiserum was produced against synthesized peptide derived from human PINX1. AA range:121-170

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 54984

Human SWISS Prot NO: Q96BK5

Subcellular Location: Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.

Research Use Only