Pirh2 Monoclonal Antibody - BT-MCA4310

Pirh2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4310-50, BT-MCA4310-100

Citations, Manuals and MSDS Available upon request.

Background: Pirh 2 (P53 induced RING-H2 protein), also known as RCHY1, it forms dimers through its N- and C-terminus in cells. The Pirh2 has ubiquitin-protein ligase activity and it binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. The Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 expression decreases the level of p53, and a decrease of endogenous Pirh2 expression increases p53 levels. Pirh2 is therefore considered, together with MDM2, to act as a negative regulator of p53 function.

Research Areas: Others

Target Protein: Pirh2

Applications: WB, IHC, ICC, FCM

Reactivity: Human, Rat

Clonality: Monoclonal

Clone ID: 1H10

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: Pirh2

Immunogen: Purified recombinant fragment of human Pirh2 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 30kDa; 60kDa (homodimer)

UniProt Accession: Q96PM5

Synonyms: ARNIP, CHIMP, RNF199, RCHY1

GeneID: 25898

Research Use Only