Product Description

Piwil2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65870-50, BS65870-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: HILI is a 973 amino acid protein encoded by the human gene PIWIL2. HILI belongs to the argonaute family and contains one PAZ domain and one PIWI domain. HILI is a cytoplasmic protein that is expressed in adμlt testis and in most tumors. It regμlates spermatogenesis and primordial germ cell production and has an essential role in meiotic differentiation of spermatocytes and in self-renewal of spermatogonial stem cells. Expression of HILI can modμlate expression of genes involved in stem cell proliferation (such as PDGFR-b), in energy metabolism (such as Glut1), in cell-cell interaction (such as Integrin a6, GJA7, THY-1 and CD9), and in germ cell differentiation (such as STRA8). It may also play a role as a regμlatory factor of Stat3/Bcl-xS/L/CCND1 pathway. Repression of HILI can inhibit tumor cell growth. HILI acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig

Host: Rabbit

Applications: WB，FCM，

Alternate Names: HILI, Hiwi like, MILI, Miwi like, Piwi like 2, Piwi-like 2, Piwil 2, Piwil-2, Piwil2, Cancer/testis antigen 80, CT80, PIWL2_HUMAN, HILI.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human Piwil2/Mili:885-973/973

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: Piwil2 Polyclonal Antibody detects endogenous levels of Piwil2 protein.

Molecular Weight: ~110kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -43°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8TC59

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only