Product Description

Piwil2 Polyclonal Antibody

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Sizes: 50µl, 100µl

Catalogue Numbers: BS65870-50, BS65870-100

Swiss-Prot: Q8TC59

Host: Rabbit

Piwil2 Polyclonal Antibody-BS65870

Storage and Stability: Store at 4°C short term. Aliquot and store at -43°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig,

Applications: WB, ，FCM，

All Applications: WB=1:500-2000

Background: HILI is a 973 amino acid protein encoded by the human gene PIWIL2. HILI belongs to the argonaute family and contains one PAZ domain and one PIWI domain. HILI is a cytoplasmic protein that is expressed in adult testis and in most tumors. It regulates spermatogenesis and primordial germ cell production and has an essential role in meiotic differentiation of spermatocytes and in self-renewal of spermatogonial stem cells. Expression of HILI can modulate expression of genes involved in stem cell proliferation (such as PDGFR-b), in energy metabolism (such as Glut1), in cell-cell interaction (such as Integrin a6, GJA7, THY-1 and CD9), and in germ cell differentiation (such as STRA8). It may also play a role as a regulatory factor of Stat3/Bcl-xS/L/CCND1 pathway. Repression of HILI can inhibit tumor cell growth. HILI acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors.

Purification and Purity: affinity purified by Protein A

Specificity: Piwil2 Polyclonal Antibody detects endogenous levels of Piwil2 protein.

Bioworld Molecular Weight: ~110kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Primary: Anti- Piwil2 at 1/300 dilution, Primary: Anti-Piwil2 at 1/1000 dilution

Alternative Name: HILI; Hiwi like; MILI; Miwi like; Piwi like 2; Piwi-like 2; Piwil 2; Piwil-2; Piwil2; Cancer/testis antigen 80; CT80; PIWL2_HUMAN; HILI.

Immunogen: KLH conjugated synthetic peptide derived from human Piwil2/Mili:885-973/973

Modification: Unmodified

Conjugate: Unconjugated