PKA C (Phospho-Thr197) Rabbit Polyclonal Antibody - BT-AP11958

PKA C (Phospho-Thr197) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP11958-20, BT-AP11958-50, BT-AP11958-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes one of the catalytic subunits of protein kinase A| which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits| in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes| including differentiation| proliferation| and apoptosis. Constitutive activation of this gene caused either by somatic mutations| or genomic duplications of regions that include this gene| have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushingandapos;s syndrome. Altern

Research Areas: Cancer; Cardiovascular; Signal transduction

Target Protein: PRKACA

Applications: WB

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: PKA C

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P17612; Mouse: P05132; Rat: P27791

Synonyms: PKA C;Thr197; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; EC 2.7.11.11

GeneID: Human: 5566; Mouse: 18747

Research Use Only