PKA C (phospho-Thr197) Rabbit Polyclonal Antibody - RA28785

PKA C (phospho-Thr197) Rabbit Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA28785-50, RA28785-100 Citations, Manuals and MSDS Available upon request. Background: protein kinase cAMP-activated catalytic subunit alpha (PRKACA) Homo sapiens This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Altern Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: WB 1:1000-2000 Alternative Names: cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) Applications: WB Species Cross-Reactivity: Human; Mouse; Rat GeneID (Human): 5566 Protein MW (KDa): 38 SWISS: P17612 Source: Rabbit Research Use Only