Product Description

PKD1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS75641-50, BS75641-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellμlar region, mμltiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regμlator of calcium permeable cation channels and intracellμlar calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modμlate G-protein-coupled signal-transduction pathways. It plays a role in renal tubμlar development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and resμlt in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: PKD1, PBP, PC1, Pc-1, TRPP1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human PKD1(NP_001009944.2).

Dilution: WB, 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Unmodification

Molecular Weight: Refer to Figures

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P98161

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only