PKD2 rabbit pAb - ES5443

PKD2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5443-50, ES5443-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Alternate Name: PRKD2; PKD2; HSPC187; Serine/threonine-protein kinase D2; nPKC-D2

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human PKD2. AA range:829-878

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 96kD

Human Gene ID: 25865

Human SWISS Prot NO: Q9BZL6

Subcellular Location: Cytoplasm. Cell membrane. Nucleus. Golgi apparatus trans-Golgi network. Translocation to the cell membrane is required for kinase activation. Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import.

Research Use Only