PKM2 (Phospho-Tyr105) Rabbit Polyclonal Antibody - BT-AP11975

PKM2 (Phospho-Tyr105) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP11975-20, BT-AP11975-50, BT-AP11975-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP| generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein| a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells| suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.

Research Areas: Epigenetics and nuclear signaling; Signal transduction; Cancer; Metabolism

Target Protein: PKM

Applications: WB

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: PKM2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P14618; Mouse: P52480; Rat: P11980

Synonyms: PKM2;Tyr105; Pyruvate kinase isozymes M1/M2; EC 2.7.1.40; Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tumor M2-PK; p58

GeneID: Human: 5315; Mouse: 18746; Rat: 25630

Research Use Only