PKN1 Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB11431-50, MB11431-100
Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Swiss-Prot: Q16512
Host: Rabbit
Reactivity: Rat
Applications: WB
All Applications: WB: 1/500-1/1000
Background: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Purification and Purity: Affinity Purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of PKN in C6Lysates using PKN1 antibody.
Bioworld Molecular Weight: Calculated MW: 104 kDa; Observed MW: 120 kDa
Specificity: IgG
Alternative Name: DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA
Immunogen: A synthetic peptide of human PKN
Conjugate: Unconjugated
Modification: Unmodified