Product Description

PLA2G2D Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS8359-50, BS8359-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Phospholipase A2s (PLA2s) constitute a family of esterases that hydrolyze the sn-2-acyl ester bond in glycerophospholipid molecμles. These enzymes are generally calcium-dependent and have been found both intra- and extracellμlarly. By hydrolyzing the sn-2 bond in glycerophospholipids, PLA2s release fatty acids. One such fatty acid, arachidonic acid, generates the substrates for the initiation of the arachidonic acid cascade that produces various eicosanoids, many of which are potent mediators of inflammation. As a member of the PLA2 family, group IID sPLA2, also known as PLA2G2D (phosphatidylcholine 2-acylhydrolase 2D), sPLA2-IID or SPLASH, is a 145 amino acid secreted protein that is broadly expressed but found at highest levels in pancreas and spleen. Group IID sPLA2 catalyzes the reaction of phosphatidylcholine and water into 1-acylglycerophosphocholine and carboxylate, and has been liked to body weight loss in patients with chronic obstructive pμlmonary disease (COPD), as well as lymphotoxin deficiency.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC, IF/ICC

Alternate Names: Group IID secretory phospholipase A2, GIID sPLA2, sPLA2-IID, PLA2IID, Phosphatidylcholine 2-acylhydrolase 2D, Secretory-type PLA, stroma-associated homolog, PLA2G2D, SPLASH

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human PLA2G2D.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF/ICC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: PLA2G2D polyclonal antibody detects endogenous levels of PLA2G2D protein.

Molecular Weight: ~ 17 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UNK4

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only