Plasma Kallikrein LC (Cleaved-I391) rabbit pAb - ES20042

Plasma Kallikrein LC (Cleaved-I391) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20042-50, ES20042-100

Citations, Manuals and MSDS Available upon request.

Background: catalytic activity:Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin., disease:Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also called Fletcher factor deficiency. This disorder is a blood coagulation defect., function:The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin., similarity:Belongs to the peptidase S1 family., similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily., similarity:Contains 1 peptidase S1 domain., similarity:Contains 4 apple domains., subunit:The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.,

Alternate Name: Plasma kallikrein (EC 3.4.21.34; Fletcher factor; Kininogenin; Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized peptide derived from human Plasma Kallikrein LC (Cleaved-I391)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 28 70kD

Human Gene ID: 3818

Human SWISS Prot NO: P03952

Subcellular Location: Secreted

Research Use Only