Product Description

Plasma Kallikrein LC (Cleaved-I391) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA28860-50, RA28860-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: catalytic activity:Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin., disease:Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also called Fletcher factor deficiency. This disorder is a blood coagulation defect., function:The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin., similarity:Belongs to the peptidase S1 family., similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily., similarity:Contains 1 peptidase S1 domain., similarity:Contains 4 apple domains., subunit:The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Plasma kallikrein (EC 3.4.21.34;Fletcher factor;Kininogenin;Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain, Plasma kallikrein light chain]

Clonality: Polyclonal

Dilution: WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight: 28 70

Protein Molecular Weight (kDa): 28 70

Storage: -20°C/1 year

Human Gene ID: 3818

Human SwissProt Number: P03952

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only