Plasminogen receptor rabbit pAb - ES8519

Plasminogen receptor rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8519-50, ES8519-100

Citations, Manuals and MSDS Available upon request.

Background: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.

Alternate Name: Plasminogen receptor (KT) (Plg-R (KT))

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human PLGRKT. AA range:1-50

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 17kD

Human Gene ID: 55848

Human SWISS Prot NO: Q9HBL7

Subcellular Location: Cell membrane; Multi-pass membrane protein. Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR.

Research Use Only