PLC gamma1 (Phospho-Ser1248) Rabbit Polyclonal Antibody - BT-AP04182

PLC gamma1 (Phospho-Ser1248) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP04182-20, BT-AP04182-50, BT-AP04182-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene catalyzes the formation of inositol 1|4|5-trisphosphate and diacylglycerol from phosphatidylinositol 4|5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example| when activated by SRC| the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi| where it activates Ras. Also| this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Research Areas: Cancer; Cardiovascular; Metabolism; Signal transduction

Target Protein: PLCG1

Applications: WB

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: PLCγ1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P19174; Mouse: Q62077; Rat: P10686

Synonyms: PLCγ1;Ser1248; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase gamma-1; EC 3.1.4.11; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1

GeneID: Human: 5335; Mouse: 18803; Rat: 25738

Research Use Only