PLCE1 Polyclonal Antibody - BT-AP13168

PLCE1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP13168-20, BT-AP13168-50, BT-AP13168-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C Catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Research Areas: Signal transduction

Target Protein: PLCE1

Applications: IHC-p, IF

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9P212; Mouse: Q8K4S1; Rat: Q99P84

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1;EC 3.1.4.11;Pancreas-enriched phospholipase C;Phosphoinositide phospholipase C-epsilon-1;Phospholipase C-epsilon-1;PLC-epsi

GeneID: Human: 51196

Research Use Only