PLCE1 rabbit pAb - ES10735

PLCE1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES10735-50, ES10735-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4, 5-bisphosphate to generate two second messengers: inositol 1, 4, 5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009],

Source: Rabbit

Applications: IHC; IF

Dilution: IHC-p 1:50-300

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized peptide derived from part region of human protein

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 253kD

Human Gene ID: 51196

Human SWISS Prot NO: Q9P212

Subcellular Location: Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Cell projection, lamellipodium. Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes.

Research Use Only