PLGF Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB9434-50, MB9434-100
Product: Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P49763(Human) P49764(Mouse) Q63434(Rat)
Host: Mouse
Reactivity: Human, Mouse, Rat
Applications: WB, IHC ICC
All Applications: WB:1:500
ICC:1:50
IHC:1:50-1:200
Background: The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include fibroblast growth factor (FGF), platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF). Like VEGF, several PlGF variants have been shown to arise from alternative mRNA splicings. Evidence has suggested VEGF to be an obligatory component in PlGF signaling. While VEGF homodimers and VEGF/PlGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PlGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PlGF. VEGF and PlGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.
Purification and Purity: Protein affinity purified.
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: PLGF monoclonal antibody detects endogenous levels of PLGF protein.
Bioworld Molecular Weight: 25 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of PLGF on JAR using anti-PLGF antibody at 1/500 dilution., ICC staining PLGF (green) in LOVO cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: PlGF, PGF, PGFL, D12S1900, Pgf, PGFL, PIGF, Placenta growth factor, Placental growth factor, Placental growth factor, vascular endothelial growth factor related protein, PlGF 2, PlGF, PLGF, PlGF2, SHGC 10760,
Immunogen: Recombinant protein within human PLGF 1-150 aa.
Conjugate: Unconjugated
Modification: Unmodified