Product Description

PLSCR1 Polyclonal Antibody

Catalogue Numbers: BS8540-50, BS8540-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O15162

Host: Rabbit

Reactivity: Human, Rat, Mouse

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Phospholipid scramblase 1 (PLSCR1) is 1 of 4 scramblases encoded in the human genome. Phospholipid scramblases function to catalyze calcium-mediated ATP-independent mobilization of phospholipids between the inner and outer leaflet of plasma membrane in activated, injured, or apoptotic cells. PLSCR1 is a type-II transmembrane protein with a short 9 amino acid C-terminal domain and a long N-terminal extracellular domain. Although PLSCR1 is part of a family of proteins that function to catalyze phospholipid mobilization, PLSCR1 may have alternative functions. Rather, PLSCR1 may function to activate cell signaling pathways, particularly in phagocytic cells of monocyte/macrophage lineage. Microglia, resident macrophages of the brain, play a key role in clearance of cellular and pathologic debris where altered phagocytosis may contribute to neurodegenerative diseases like Alzheimer’s disease. PLSCR1 may regulate microglia phagocytosis, representing a potential therapeutic target to modulate microglia phagocytosis.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PLSCR1 polyclonal antibody detects endogenous levels of PLSCR1 protein.

Extra Notes: Western blot (WB) analysis of PLSCR1 polyclonal antibody at 1:500 dilution
LaneA:H9C2 whole cell lysate(40ug)
LaneB:CT26 whole cell lysate(40ug)
LaneC:HepG2 whole cell lysate(40ug)
LaneD:HCT116 whole cell lysate(40ug)

Bioworld Molecular Weight: ~ 36 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Phospholipid scramblase 1; PL scramblase 1; Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; Mg(2+)-dependent nuclease ; PLSCR1

Immunogen: Synthetic peptide, corresponding to Human PLSCR1.

Conjugate: Unconjugated

Modification: Unmodified