Product Description

POLE3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS8241-50, BS8241-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: DNA replication is initiated by the binding of initiation factors to the origin of replication. Nucleosomes inhibit access to the replication machinery at these origin sequences. Nucleosome remodeling factors increase the accessibility of nucleosomal DNA to transcriptional regμlators . CHRAC15 and CHRAC17 are subunits of the nucleosomal remodeling factor CHRAC (chromatin accessibility complex), which increases the accessibility of nucleosomal DNA in an ATP-dependent manner . Unlike other known chromatin remodelling factors, CHRAC also functions during chromatin assembly by using ATP to convert irregμlar chromatin into a regμlar array of nucleosomes with even spacing . This conversion process occurs when CHRAC organizes randomly deposited histones into a regμlarly spaced array . In the presence of CHRAC, the nucleosomal ATPase ISWI catalyses several ATP-dependent transitions of chromatin structure .

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IF

Alternate Names: DNA polymerase epsilon subunit 3, Arsenic-transactivated protein, AsTP, Chromatin accessibility complex 17 kDa protein, CHRAC-17, HuCHRAC17, DNA polymerase II subunit 3, DNA polymerase epsilon subunit p17, POLE3, CHRAC17

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human POLE3.

Dilution: WB: 1:500~1:2000
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: POLE3 polyclonal antibody detects endogenous levels of POLE3 protein.

Molecular Weight: ~ 20-25 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9NRF9

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only