Product Description

POLR3C Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA28922-50, RA28922-100

Citations, Manuals and MSDS Available upon request.

Background: disease:Antibodies against POLR3C were found in the sera of patients with systemic sclerosis (SSc) .,function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation.,similarity:Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.,subunit:Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity) . RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex. Interacts with GTF3C4.,

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Alternative Names: POLR3C; DNA-directed RNA polymerase III subunit RPC3; RNA polymerase III subunit C3; DNA-directed RNA polymerase III subunit C; RNA polymerase III 62 kDa subunit; RPC62

Applications: WB; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 10623

Protein MW (KDa): 60

SWISS: Q9BUI4

Source: Rabbit

Research Use Only