Postmeiotic Segregation Increased 2 (PMS2) Mouse Monoclonal Antibody (PT2116) - RA12267

Postmeiotic Segregation Increased 2 (PMS2) Mouse Monoclonal Antibody (PT2116)

Size: 50μL, 100μL

Catalogue Numbers: RA12267-50, RA12267-100

Citations, Manuals and MSDS Available upon request.

Background: PMS1 homolog 2, mismatch repair system component (PMS2) Homo sapiens The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA (X) 2E (X) 4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.151% sodium azide.

Storage Instructions: -20°C/1 year

Applications: IHC-p; IF (paraffin section)

Species Cross-Reactivity: Human

GeneID (Human): 5395

SWISS: P54278

Source: Mouse

Research Use Only