POT1 rabbit pAb - ES3245

POT1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES3245-50, ES3245-100

Citations, Manuals and MSDS Available upon request.

Background: protection of telomeres 1 (POT1) Homo sapiens This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008],

Alternate Name: POT1; Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Monkey

Immunogen: The antiserum was produced against synthesized peptide derived from human POT1. AA range:247-296

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 70kD

Human Gene ID: 25913

Human SWISS Prot NO: Q9NUX5

Subcellular Location: Nucleus. Chromosome, telomere. Colocalizes with telomeric DNA.

Research Use Only