Product Description

POTEG Polyclonal Antibody

Catalogue Numbers: BS62434-50, BS62434-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Swiss-Prot: Q6S5H5; Q6S545; A6NI47

Host: Rabbit

Reactivity: Human, Rat, Mouse

Applications: WB IHC

All Applications: WB:1:500~1:1000 IHC:1:50~1:200

Background: POTE ankyrin domain family, member G ( poteg ) belongs to POTE family. The POTE family is composed of many proteins which are very closely related and expressed in prostate, ovary, testis, and placenta. Some POTE paralogs are related with some cancers. Here we showed that down‐regulation of POTEG was detected in about 60% primary esophageal squamous cell carcinoma (ESCC) tumor tissues. Clinical association studies determined that POTEG down‐regulation was significantly correlated with tumor differentiation, lymph nodes metastasis and TNM staging. Kaplan‐Meier analysis determined that POTEG down‐regulation was associated with poorer clinical outcomes of ESCC patients ( P = 0.026). Functional studies showed that POTEG overexpression could suppress tumor cell growth and metastasis capacity in vitro and in vivo. Molecular analyses revealed that POTEG downregulated CDKs, leading to subsequent inhibition of Rb phosphorylation, and consequently arrested Cell Cycle at G1/S Checkpoint.

Purification and Purity: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.

Specificity: POTEG polyclonal antibody detects endogenous levels of POTEG protein.

Extra Notes: Western blot (WB) analysis of POTEG polyclonal antibody at 1:500 dilution
LaneA:A549 whole cell lysate
LaneB:The testis tissue lysate of Mouse
LaneC:The testis tissue lysate of Rat
LaneD:The brain tissue lysate of Mouse

Bioworld Molecular Weight: ~ 58,54 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: POTE ankyrin domain family member G; ANKRD26-like family C member 2; Prostate, ovary, testis-expressed protein on chromosome 14; POTE-14; POTEG; A26C2; POTE14

Immunogen: Synthetic peptide, corresponding to Human POTEG.

Conjugate: Unconjugated

Modification: Unmodified