Product Description

POTEG Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS62434-50, BS62434-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: POTE ankyrin domain family, member G ( poteg ) belongs to POTE family. The POTE family is composed of many proteins which are very closely related and expressed in prostate, ovary, testis, and placenta. Some POTE paralogs are related with some cancers. Here we showed that down‐regμlation of POTEG was detected in about 60% primary esophageal squamous cell carcinoma (ESCC) tumor tissues. Clinical association studies determined that POTEG down‐regμlation was significantly correlated with tumor differentiation, lymph nodes metastasis and TNM staging. Kaplan‐Meier analysis determined that POTEG down‐regμlation was associated with poorer clinical outcomes of ESCC patients ( P = 0.026). Functional studies showed that POTEG overexpression coμld suppress tumor cell growth and metastasis capacity in vitro and in vivo. Molecμlar analyses revealed that POTEG downregμlated CDKs, leading to subsequent inhibition of Rb phosphorylation, and consequently arrested Cell Cycle at G1/S Checkpoint.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, IHC

Alternate Names: POTE ankyrin domain family member G, ANKRD26-like family C member 2, Prostate, ovary, testis-expressed protein on chromosome 14, POTE-14, POTEG, A26C2, POTE14

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human POTEG.

Dilution: WB:1:500~1:1000 IHC:1:50~1:200

Purification: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Specificity: POTEG polyclonal antibody detects endogenous levels of POTEG protein.

Molecular Weight: ~ 58, 54 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.

SwissProt: Q6S5H5, Q6S545, A6NI47

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Research Use Only