PP2B-Aα rabbit pAb - ES20264

PP2B-Aα rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20264-50, ES20264-100

Citations, Manuals and MSDS Available upon request.

Background: catalytic activity:A phosphoprotein + H (2)O = a protein + phosphate., cofactor:Binds 1 Fe (3+) ion per subunit., cofactor:Binds 1 zinc ion per subunit., function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1., online information:Calcineurin entry, similarity:Belongs to the PPP phosphatase family., similarity:Belongs to the PPP phosphatase family. PP-2B subfamily., subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle., subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.,

Alternate Name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform)

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human PP2B-Aα

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 5530

Human SWISS Prot NO: Q08209

Subcellular Location: Cytoplasm. Cell membrane; Peripheral membrane protein. Cell membrane, sarcolemma. Cytoplasm, myofibril, sarcomere, Z line. Cell projection, dendritic spine. Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca (2+)-channel activation (PubMed:22343722).

Research Use Only