Product Description

PPM1K Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS62439-50, BS62439-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: PP2Cκ (protein phosphatase 2C isoform κ), also known as PP2C-type mitochondrial phosphoprotein phosphatase and PP2C domain-containing protein phosphatase 1K, is a 372 amino acid mitochondrial matrix protein that regμlates the opening of mitochondrial membrane permeability transition pores. PP2Cκ is essential for cell survival, cardiac function and embryonic development. Knockdown of PP2Cκ resμlts in cell death due to loss of mitochondrial membrane potential. PP2Cκ specifically binds to the branched-chain-αketoacid dehydrogenase (BCKD) complex and induces dephosphorylation of Ser293, effectively leading to the inhibition of branched chain amino acid metabolism. Highest expression of PP2Cκ is found in brain, diaphragm and heart. There are three isoforms of PP2Cκ that are produced as a resμlt of alternative splicing events.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, IHC

Alternate Names: Protein phosphatase 1K, mitochondrial, PP2C domain-containing protein phosphatase 1K, PP2C-like mitochondrial protein, PP2C-type mitochondrial phosphoprotein phosphatase, PTMP, Protein phosphatase 2C isoform kappa, PP2C-kappa, PPM1K, PP2CM

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human PPM1K.

Dilution: WB:1:500~1:1000 IHC:1:50~1:200

Purification: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Specificity: PPM1K polyclonal antibody detects endogenous levels of PPM1K protein.

Molecular Weight: ~ 34, 36 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8N3J5

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Research Use Only