
PPM1M Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-53113-60, E-AB-53113-120, E-AB-53113-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: PPM1M
Target Synonym: FLJ32332; PP2C eta; PP2C-eta; PP2CE; PP2Ceta; PPM1M; PPM1M; protein phosphatase 1M (PP2C domain containing); Protein phosphatase 1M; Protein phosphatase 2C isoform eta
Research Areas: Signal transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse
Application: IHC, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q96MI6
Background: PPM1M is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase was identified as an interacting protein of Rho guanine nucleotide exchange factors (PIX). PIX proteins are regulators of p21/Cdc42/Rac1-activated kinase 1 (PAK1), a protein kinase mediating biological effects downstream of Rho GTPases. This phosphatase has been shown to block the effects of PAK, and thus inhibit actin stress fiber breakdown and morphological changes driven by cell division cycle 42 (CDC42).
Concentration: 0.78 mg/mL
Immunogen: Fusion protein of human PPM1M
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method: Antigen affinity purification
Dilution: IHC 1:50-1:200, ELISA 1:5000-1:10000
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only