Product Description

PPP1R13B Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60843-50, BS60843-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: ASPP proteins interact with p53 and are responsible for enhancing p53-induced apoptosis but not cell cycle arrest. Inhibition of endogenous ASPP1 (PPP1R13B) function inhibits the apoptotic function of endogenous p53 in response to apoptotic stimμli. ASPP1 amplifies DNA binding and transactivation function of p53 on the promoters of proapoptotic genes in vivo. Expres-sion of ASPP1 is often downregμlated in human breast carcinomas expressing wildtype p53, but not in those expressing mutant p53. This research indicates that ASPP1 regμlates the tumor suppression function of p53 in vivo. ASPP1 is predominantly a cytoplasmic protein, although some fraction of the polypeptide is nuclear. Defects in PPP1R13B, the gene which encodes ASPP1, may be a cause of breast cancers. The deduced ASPP1 protein contains 1, 090 amino acid residues.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Apoptosis-stimμlating of p53 protein 1, Protein phosphatase 1 regμlatory subunit 13B, PPP1R13B, ASPP1, KIAA0771

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human PPP1R13B.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: PPP1R13B polyclonal antibody detects endogenous levels of PPP1R13B protein.

Molecular Weight: ~ 119 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -21°C long term. Avoid freeze-thaw cycles.

SwissProt: Q96KQ4

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only