Product Description

PPP1R15B Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA28958-50, RA28958-100

Citations, Manuals and MSDS Available upon request.

Background: protein phosphatase 1 regulatory subunit 15B (PPP1R15B) Homo sapiens This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with mi

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.

Alternative Names: PPP1R15B; Protein phosphatase 1 regulatory subunit 15B

Applications: WB; IHC-p; IF (paraffin section) ; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 84919

Protein MW (KDa): 78

SWISS: Q5SWA1

Source: Rabbit

Research Use Only