Product Description

Pqbp1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS77852-50, BS77852-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regμlation, innate immunity and neuron development (By similarity. Interacts with splicing-related factors via the intrinsically disordered region and regμlates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner (By similarity. Can activate transcription directly or via association with the transcription machinery (By similarity. May be involved in ATXN1 mutant-induced cell death (By similarity. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (By similarity. Involved in the assembly of cytoplasmic stress granμle, possibly by participating in the transport of neuronal RNA granμles (By similarity. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol (By similarity. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (By similarity.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: PQBP-1, Sfc2, npw38

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of mouse Pqbp1(NP_062351.2).

Dilution: WB, 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Unmodification

Molecular Weight: 35kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q91VJ5

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only