Product Description

PRAK Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA28982-50, RA28982-100

Citations, Manuals and MSDS Available upon request.

Background: mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5) Homo sapiens The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Alternative Names: MAPKAPK5; PRAK; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; p38-regulated/activated protein kinase; PRAK

Applications: WB; ELISA

Species Cross-Reactivity: Human; Mouse

GeneID (Human): 8550

Protein MW (KDa): 60

SWISS: Q8IW41

Source: Rabbit

Research Use Only