PRDX2 Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB9449-50, MB9449-100
Product: Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P32119(Human)
Host: Mouse
Reactivity: Human
Applications: WB, FC
All Applications: WB:1:2,000-1:5,000
FC:1:50-1:100
Background: The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX I gene encodes a protein that is expressed in several tissues, including liver, kidney, testis, lung and nervous system. PRX II is expressed in testis, while PRX III shows expression in lung. PRX I, II and III are overexpressed in breast cancer and may be involved in its development or progression. Upregulated protein levels of PRX I and II in Alzheimer's disease (AD) and Down syndrome (DS) indicate the involvement of PRX I and II in their pathogenesis.
Purification and Purity: ProG affinity purified.
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: PRDX2 monoclonal antibody detects endogenous levels of PRDX2 protein.
Bioworld Molecular Weight: 22 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Peroxiredoxin 2 on PC-3M (1) and MCF-7 (2) using anti-Peroxiredoxin 2 antibody at 1/5,000 dilution., Flow cytometric analysis of PC-3M cells with Peroxiredoxin 2 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-mouse IgG1 was used as the secondary antibody.
Alternative Name: NKEF-B, TSA, PRDX2, NKEFB, TDPX1, Epididymis secretory sperm binding protein Li 2a, HEL S 2a, MGC4104, Natural killer cell enhancing factor B, Natural killer cell-enhancing factor B, Natural Killer Enhancing Factor B, NKEF B, NKEF-B, NKEFB, Peroxiredoxin-2, PRDX 2, PRDX2, PRDX2, PrP, PRX2, PRXII, PTX1, TDPX1, Thiol Specific Antioxidant 1, Thiol specific antioxidant protein, Thiol-specific antioxidant protein, Thioredoxin Dependent Peroxide Reductase 1, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, Torin, TPX1, TSA,
Immunogen: Recombinant protein.
Conjugate: Unconjugated
Modification: Unmodified