PRDX6 Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB9450-50, MB9450-100
Product: Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P30041(Human)
Host: Mouse
Reactivity: Human
Applications: WB, IHC ICC FC
All Applications: WB:1:500
ICC:1:50-1:200
IHC:1:100-1:400
FC:1:50-1:100
Background: The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization.PRX VI, a 1-Cys peroxiredoxin (also known as antioxidant protein 2 or AOP2), is highly expressed in most tissues, particularly in epithelial cells. Localized to the cell cytosol, PRX VI functions independently of other peroxiredoxins and antioxidant proteins, specializing in antioxidant defense, lung phospholipid metabolism and protection of keratinocytes from cell death induced by reactive oxygen species.
Purification and Purity: ProG affinity purified.
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: PRDX6 monoclonal antibody detects endogenous levels of PRDX6 protein.
Bioworld Molecular Weight: 25 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of PRDX6 on PC-3M (1) and K562 (2) using anti-PRDX6 antibody at 1/500 dilution., ICC staining PRDX6 (green) in A431 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: 1-Cys PRX, aiPLA2, NSGPx, PRDX6, AOP2, KIAA0106, 1 Cys, 1 Cys peroxiredoxin, 1 Cys PRX, 1 cysPrx, 1-Cys peroxiredoxin, 1-Cys PRX, 24 kDa protein, 9430088D19Rik, AA690119, Acidic calcium independent phospholipase A2, Acidic calcium-independent phospholipase A2, aiPLA2, Antioxidant protein 2, AOP2, Aop2 rs3, Brp 12, Ciliary body glutathione peroxidase, CP 3, EC 1.11.1.15, EC 1.11.1.7, EC 3.1.1., Epididymis secretory sperm binding protein Li 128m, GPx, HEL S 128m, KIAA0106, Liver 2D page spot 40, Ltw4, Lvtw 4, MGC46173, mKIAA0106, Non selenium glutathione peroxidase, Non-selenium glutathione peroxidase, NSGPx, ORF06, OTTHUMP00000032693, p29, Peroxiredoxin-6, Peroxiredoxin6, PHGPx, Phospholipase A2 lysosomal, PLA2, PRDX 6, Prdx5, PRDX6, Prdx6 rs3, PRDX6, PRX, Red blood cells page spot 12, Thiol specific antioxidant protein,
Immunogen: Recombinant protein.
Conjugate: Unconjugated
Modification: Unmodified