Presenilin 1 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA29002-50, RA29002-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: presenilin 1 (PSEN1) Homo sapiens Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008], Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, IHC-p, IF (paraffin section), ELISA Alternate Names: PSEN1, AD3, PS1, PSNL1, Presenilin-1, PS-1, Protein S182 Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. Molecular Weight: 43 Protein Molecular Weight (kDa): 43 Storage: -20°C/1 year Human Gene ID: 5663 Human SwissProt Number: P49768 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only