Presenilin 2 rabbit pAb - ES20221

Presenilin 2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20221-50, ES20221-100

Citations, Manuals and MSDS Available upon request.

Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008],

Alternate Name: Presenilin-2 (PS-2; EC 3.4.23.-; AD3LP; AD5; E5-1; STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human Presenilin 2 AA range: 270-350

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 5664

Human SWISS Prot NO: P49810

Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.

Research Use Only