Presenilin 2 Rabbit Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA29004-50, RA29004-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: presenilin 2 (PSEN2) Homo sapiens Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008], Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, ELISA Alternate Names: Presenilin-2 (PS-2;EC 3.4.23.-;AD3LP;AD5;E5-1;STM-2) [Cleaved into: Presenilin-2 NTF subunit, Presenilin-2 CTF subunit] Clonality: Polyclonal Dilution: WB 1:1000-2000 ELISA 1:5000-20000 Storage: -20°C/1 year Human Gene ID: 5664 Human SwissProt Number: P49810 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only