Product Description

PRKAR2A (PKA R2 ) Mouse Monoclonal Antibody

Sizes: 25μl, 100μl

Catalogue Numbers: MB4176-25, MB4176-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: cAMP is a signaling molecμle important for a variety of cellμlar functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regμlatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regμlatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regμlatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regμlatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellμlar localization of cAMP-dependent protein kinase. This subunit has been shown to regμlate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticμlum (ER).

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: FC, IF, IHC, WB

Alternate Names: PKR2, PRKAR2

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Fμll length human recombinant protein of human PRKAR2A (NP_004148) produced in HEK293T cell.

Dilution: WB 1:1000, IHC 1:50, IF 1:100, Flow: 1:100

Purification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IgG1

Molecular Weight: 45.3 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P13861

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only