PRMT6 Monoclonal Antibody - BT-MCA1066

PRMT6 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1066-50, BT-MCA1066-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.

Research Areas: Epigenetics and nuclear signaling

Target Protein: PRMT6

Applications: WB, IHC-p, IF, ICC

Reactivity: Human,Mouse,Rat

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Protein arginine N-methyltransferase 6

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q96LA8; Mouse: Q6NZB1

Synonyms: PRMT6; HRMT1L6; Protein arginine N-methyltransferase 6; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6

GeneID: Human: 55170; Mouse: 99890

Research Use Only