Product Description

PRMT7 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11459-50, MB11459-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q9NVM4

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB,

All Applications: WB: 1/500-1/1000

Background: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 78 kDa; Observed MW: 78 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of PRMT7 in rat muscle, rat pancreas lysates using PRMT7 antibody., Western blot analysis of PRMT7 in K562, 3T3, Hela lysates using PRMT7 antibody.

Alternative Name: SBIDDS

Immunogen: A synthetic peptide of human PRMT7

Conjugate: Unconjugated

Modification: Unmodified