PROC Polyclonal Antibody-BS60875

PROC Polyclonal Antibody

Catalogue Numbers: BS60875-50, BS60875-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P04070

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Protein C is a vitamin K-dependent plasma protein that is produced in the liver and made up of two polypeptide chains. It is an important anti-coagulant activated by Thrombin bound to an endothelial surface receptor and it enzymatically cleaves activated forms of Factors V and VIII, thus inhibiting blood coagulation. Protein C is similar to the prothrombin group of blood coagulation factors in its primary structure. Normal protein C concentration in human plasma is approximately 1-3 ng/ml and the proenzyme concentration is approximately 3 µg/ml. Protein C deficiency is associated with inherited thrombophilia, a rare genetic disorder that predisposes affected individuals to venous thrombosis and habitual abortion.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PROC polyclonal antibody detects endogenous levels of PROC protein.

Extra Notes: Western blot (WB) analysis of PROC pAb at 1:500 dilution
Lane1:RAW264.7 whole cell lysate(40ug)
Lane2:HepG2 whole cell lysate(40ug)
Lane3:Jurkat whole cell lysate(40ug)
Lane4:HEK293T whole cell lysate (40ug)

Bioworld Molecular Weight: ~ 52 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Vitamin K-dependent protein C (EC:3.4.21.69); Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide; PROC

Immunogen: A synthetic peptide corresponding to residues in Human PROC.

Conjugate: Unconjugated

Modification: Unmodified